Non-coding RNA in hematopoietic development and cancer


The control of hematopoietic differentiation and its dysregulation in leukemia is complex- and many newly discovered elements of gene expression regulation play important roles.  We have recently made some important inroads into microRNA- and long non-coding RNA- dependent regulation of B-cell differentiation and leukemogenesis.  Our research points to critical roles played by non-traditional modes of gene regulation in hematopoiesis and cancer. It's our goal to understand these roles and to determine how we can leverage these novel mechanisms in the diagnosis and treatment of human diseases.